In this practical guide, we highlight four key areas to consider when building a system of supports and opportunities that addresses young people's unique needs, including those with learning differences. According to the National Center for Learning Disabilities, one in five children experience learning and attention issues with only a small portion of these children receiving formal diagnoses. Our research examines strategies for creating high-quality programs and services that are responsive to the needs of all young people, including those with learning differences. Key areas for stakeholders to consider include constructing children's cabinets or working groups, expanding learning opportunities, integrating social and emotional health services, and personalizing learning. In each core area, we identify concrete actions to undertake, from ensuring that the special education community is represented on Children's Cabinets to coordinating care between in-school and out-of-school settings. This guide also contains a list of relevant resources.